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Major Depressive Disorder

Depression is a complex disease encompassing multiple subtypes that include MDD, dysthymic disorder, psychotic depression, postpartum depression and seasonal affective disorder. MDD is the most prominent subtype of depression. The following symptoms are typically associated with MDD:

  • Depressed Mood. People suffering from MDD typically have depressed spirit or mood, known as dysphoria, which can be worse in the morning, reduced energy and decreased activity level, as well as loss of libido. Lowered mood may vary little from day to day.
  • Reduced Concentration and Overall Tiredness. People suffering from MDD also have a reduced capacity for enjoyment, and their interest level in life and general concentration is reduced. In addition, these individuals can experience marked tiredness after minimal effort. MDD may be accompanied by so-called “somatic” symptoms, such as loss of interest in pleasurable feelings, or anhedonia, and early morning walking.
  • Sleep Disturbance and Diminished Appetites. People suffering from MDD may also experience sleep disturbances, which is the difficulty falling or staying asleep, and they may also experience a diminished appetite, which can result in weight loss.
  • Lowered Self Esteem. People suffering from MDD may also experience a lowered self-esteem and reduced self-confidence. Ideas of guilt and worthlessness are often present.

While the exact cause of MDD is unknown, psychological, biological, genetic and environmental factors contribute to its onset.

Biologically, monoamines serotonin, or 5-HT, norepinephrine, and dopamine are three of the main neurotransmitters thought to be involved in MDD. When there is a chemical imbalance in these neurotransmitters, depression is likely to develop. The identification of these and other neurotransmitters linked to the development of MDD has been the focus for the development of a drug therapy to treat the symptoms of MDD.

Learn more about why we are developing MIN-117 to treat major depressive disorder.

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